When it comes to skin repair and regeneration, growth factors are some of the most exciting and effective ingredients in modern aesthetics. One standout is PDGF, or Platelet-Derived Growth Factor- a lab engineered compound that plays a powerful role in cellular healing and tissue regeneration.
PDGF is a naturally occurring protein in the body, released by platelets in response to injury. Its job? To signal nearby cells to begin the repair process, stimulating the growth of new cells, the production of collagen, and the formation of new blood vessels.
In aesthetic and medical skincare, PDGF used in products is lab-derived, meaning it’s bioengineered under sterile, controlled conditions (not taken from human blood or tissue). This makes it not only safe and stable but also consistent in potency! Perfect for use in medical-grade treatments and skincare products.
Lab-derived PDGF is used in both topical formulations and in-office procedures to support skin healing and rejuvenation. It’s especially helpful after treatments that create controlled injury to the skin, such as:
When applied post-treatment, PDGF accelerates healing, reduces inflammation, and enhances results by boosting collagen production and tissue repair.
In addition to topical use, PDGF can also be injected as part of advanced rejuvenation treatments. When injected, it can help with:
PDGF isn’t just a buzzword — it’s FDA-approved under the name becaplermin gel (Regranex) for the treatment of diabetic foot ulcers. This approval underscores its proven ability to aid in wound healing, which has opened the door for its broader use in cosmetic and dermatological applications.
While the FDA approval is specifically for chronic wound treatment, its mechanism- stimulating fibroblasts and encouraging angiogenesis, makes it ideal for supporting skin and hair rejuvenation in aesthetic medicine.
When used appropriately, PDGF offers a wide range of benefits:
Because it mimics the body's natural healing signals, it’s generally well-tolerated and can be used across a range of skin types and concerns.
PDGF represents the intersection of science and skincare, a potent, lab-developed growth factor that supports healing and enhances aesthetic results. Whether applied topically, used post-procedure, or injected for deeper rejuvenation, it helps patients see better results, faster healing, and more radiant skin.
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